Characterization of the myocardium in the 4-chamber view using accelerated free-breathing diffusion tensor MRI

Background Diffusion Tensor MRI (DTI) of the heart in vivo has conventionally been performed in the short-axis of the left ventricle (LV) [1]. While this allows all three coronary territories to be seen, the short-axis acquisition orientation has some limitations. Full coverage of the LV in the short-axis requires roughly 12 to 15 slices, and accurate evaluation of the apex of the heart is often compromised. In addition, a nominal slice thickness of 8 mm is routinely used. An accelerated free-breathing DTI acquisition of the heart in its horizontal long-axis (4-chamber view) would require fewer slices (6), reduce acquisition time, and improve the characterization of the anterior and apical walls. A 4-chamber view, previously not performed, may be particularly useful when studying the remodeling of these regions.