Pii: S0010-4825(98)00045-6
نویسندگان
چکیده
The computational method of constrained constructive optimization (CCO) has been generalized in two important respects: (1) arterial model trees are now grown within a convex, three-dimensional piece of tissue and (2) terminal ̄ow variability has been incorporated into the model to account for the heterogeneity of blood ̄ow observed in real vascular beds. Although no direct information from topographic anatomy enters the model, computer-generated CCO trees closely resemble corrosion casts of real arterial trees, both on a visual basis and with regard to morphometric parameters. Terminal ̄ow variability was found to induce transitions in the connective structure early in the trees' development. The present generalization of CCO oers Ð for the ®rst time Ð the possibility to generate optimized arterial model trees in three dimensions, representing a realistic geometrical substrate for hemodynamic simulation studies. With the implementation of terminal ̄ow variability the model is ready to simulate processes such as the adaptation of arterial diameters to changes in blood ̄ow rate or the formation of dierent patterns of angiogenesis induced by changing needs of blood supply.# 1999 Elsevier Science Ltd. All rights reserved.
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