Does Long-Term Itraconazole Prophylaxis Result in In Vitro Azole Resistance in Mucosal Candida albicans Isolates from Persons with Advanced Human Immunodeficiency Virus Infection?
نویسندگان
چکیده
MITCHELL GOLDMAN, GRETCHEN A. CLOUD, MELINDA SMEDEMA, ANN LEMONTE, PATRICIA CONNOLLY, DAVID S. MCKINSEY, CAROL A. KAUFFMAN, BRUCE MOSKOVITZ, L. JOSEPH WHEAT,* AND THE NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES MYCOSES STUDY GROUP† School of Medicine and Histoplasmosis Reference Laboratory, Indiana University; and Veterans’ Affairs Medical Center, Indianapolis, Indiana; University of Alabama at Birmingham, Birmingham, Alabama; Infectious Disease Associates of Kansas City, Kansas City, Missouri; University of Michigan and Veterans Affairs Medical Center, Ann Arbor, Michigan; and Janssen Research Foundation, Beerse, Belgium
منابع مشابه
Distributions and antifungal susceptibility of Candida species from mucosal sites in HIV positive patients.
BACKGROUND Mucocutaneous candidiasis (almost endogenous) is one of the most common manifestations of human immunodeficiency virus (HIV) infection. The aim of this study was the investigation of colonization patterns of Candida species, particularly C. dubliniensis, among mucosal sites of HIV-positive patients and determining corresponding in vitro susceptibility patterns to the antifungals. M...
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Isavuconazole is a novel, broad-spectrum, antifungal azole. In order to evaluate its interactions with known azole resistance mechanisms, isavuconazole susceptibility among different yeast models and clinical isolates expressing characterized azole resistance mechanisms was tested and compared to those of fluconazole, itraconazole, posaconazole, and voriconazole. Saccharomyces cerevisiae expres...
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Azole antifungal agents, and especially fluconazole, have been used widely to treat oropharyngeal candidiasis in patients with AIDS. An increasing number of cases of clinical resistance against fluconazole, often correlating with in vitro resistance, have been reported. To investigate the mechanisms of resistance toward azole antifungal agents at the molecular level in clinical C. albicans isol...
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