HLA system and side effects of gold salts and D-penicillamine treatment of rheumatoid arthritis.
نویسندگان
چکیده
Among 67 patients with rheumatoid arthritis treated with gold salts (aurothiopropanol sulphonate) a significant correlation (p less than 10(-2)) was noted between gold toxic reactions, whatever their type, and the HLA antigens A1, B8, Cw7, and DR3. Forty-two patients were genotyped, and a correlation was observed between gold side effects and the haplotype A1 Cw7 B8 DR3 (p less than 10(-2), RR = 8.0). In addition 3 out of 4 cases of renal intolerance to D-penicillamine were observed in patients possessing the Cw7 B8 DR3 haplotype.
منابع مشابه
[D-penicillamine in the treatment of rheumatoid arthritis].
Forty-four patients with definite or classic rheumatoid arthritis and failure to tolerate or respond to gold therapy were treated with D-penicillamine on a so-called go-slow, go-low regime. Seventeen patients tolerated the drug and had a 3-13 month follow-up assessment; 8 were markedly improved, 6 moderately or slightly improved, and 3 unimproved. Penicillamine had to be discontinued in 9 patie...
متن کاملHLA types in patients with rheumatoid arthritis developing leucopenia after both gold and sulphasalazine treatment.
HLA types, especially HLA-DR3, are associated with the development of toxic reactions in patients with rheumatoid arthritis after treatment with gold or D-penicillamine. In this study, after treatment with sulphasalazine, leucopenia was observed in three patients, who all had a history of leucopenia after previous gold treatment. The HLA types of these patients did not include HLA-DR3; the two ...
متن کاملAssociation of different HLA antigens with various toxic effects of gold salts in rheumatoid arthritis.
An association of gold induced proteinuria with HLA-D(R)3 has been reported. To investigate other possible relationships between gold toxicity and HLA antigens we studied 85 patients with rheumatoid arthritis (RA) divided into four subgroups: patients with gold induced interstitial pneumonitis, mucocutaneous lesions, proteinuria, and patients without gold toxicity. The HLA frequencies in patien...
متن کاملSurvival analysis of disease modifying antirheumatic drugs in Spanish rheumatoid arthritis patients.
OBJECTIVES To evaluate the duration of treatment and the reasons for discontinuing therapy with disease modifying antirheumatic drugs in Spanish rheumatoid arthritis patients. METHODS An observational study was made of 629 patients with rheumatoid arthritis treated with disease modifying antirheumatic drugs between 1979 and 1991. The outcomes (treatment termination because of toxicity and lac...
متن کاملPenicillamine in the treatment of rheumatoid arthritis.
Between 1973 and 1979, 203 patients with classical or definite rheumatoid arthritis were treated with chloroquine phosphate, gold, or penicillamine. Of 132 receiving penicillamine, 76 received it as the sole treatment. Forty of 50 withdrawals from penicillamine were side effect-related, although 4 of these 50 subsequently resumed therapy. Nineteen showed no response to penicillamine. Eight-six ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Annals of the rheumatic diseases
دوره 41 6 شماره
صفحات -
تاریخ انتشار 1982