Wernicke's encephalopathy in a non-alcoholic Patient: Difficulties of early diagnosis and treatment
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The incidence of Wernicke's encephalopathy in Australia--a neuropathological study of 131 cases.
In a nine year necropsy study in Western Australia, the incidence of Wernicke's encephalopathy was 2.8%. The incidence appears to be increasing. Although Wernicke's encephalopathy is a nutritional disorder, the majority of cases occur in the alcoholic population. Only 20% of the 131 cases studied had been diagnosed clinically as Wernicke's encephalopathy. This large discrepancy between numbers ...
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BACKGROUND The cholinergic nucleus basalis (Ch4) is an exclusive site of neurofibrillary degeneration in alcoholic patients with Wernicke's encephalopathy. AIM To test the hypothesis that the loss of Ch4 neurons contributes to the memory disorder, Korsakoff's psychosis, commonly seen in Wernicke's encephalopathy. METHODS Magnocellular basal forebrain neurons were quantified in alcoholic pat...
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Wernicke's encephalopathy (WE) is a disease usually related to chronic alcoholism. The clinical diagnosis is often difficult to establish. MR imaging is a highly sensitive method for detecting lesions associated with Wernicke's encephalopathy. We report a case of atypical manifestation of hyperintense lesions on magnetic resonance imaging (MRI) in a 60-year-old male patient with Wernicke's ence...
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Wernicke's encephalopathy is usually associated with chronic alcohol abuse.' It may also occur in other clinical contexts including hyperemesis gravidarum,2-4 inadequate diet due to malabsorption, forced or self-imposed starvation, anorexia and prolonged intravenous feeding.7 I report a case of severe Wernicke's encephalopathy where the presence ofpapilloedema caused potentially serious delay i...
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