The development and biology of bradyzoites of Toxoplasma gondii.

Anterior uveitis in a kitten infected with Toxoplasma gondii (Tehran strain)

Ocular lesions are a common manifestation of toxoplasmosis in cats. In this survey, 10 healthy Syrianmice were infected through intraperitoneal inoculation of bradyzoites of Toxoplasma gondii (Tehran strain).Mice were killed 30 days after inoculation and the suspension of their brains was prepared, after confirmationof the infection. Seven kittens were fed with the infected mice brain suspensio...

W . Bohne , D . S . Roos and M . W . Development Sporozoite - InitiatedSpontaneously during Bradyzoites Form Toxoplasma Gondii

Unexpected oocyst shedding by cats fed Toxoplasma gondii tachyzoites: in vivo stage conversion and strain variation.

Tachyzoites, bradyzoites (in tissue cysts), and sporozoites (in oocysts) are the three infectious stages of Toxoplasma gondii. The prepatent period (time to shedding of oocysts after primary infection) varies with the stage of T. gondii ingested by the cat. The prepatent period (pp) after ingesting bradyzoites is short (3-10 days) while it is long (18 days or longer) after ingesting oocysts or ...

Novel Approaches Reveal that Toxoplasma gondii Bradyzoites within Tissue Cysts Are Dynamic and Replicating Entities In Vivo

UNLABELLED Despite their critical role in chronic toxoplasmosis, the biology of Toxoplasma gondii bradyzoites is poorly understood. In an attempt to address this gap, we optimized approaches to purify tissue cysts and analyzed the replicative potential of bradyzoites within these cysts. In order to quantify individual bradyzoites within tissue cysts, we have developed imaging software, BradyCou...

Identification of compounds that suppress Toxoplasma gondii tachyzoites and bradyzoites

Drug treatment for toxoplasmosis is problematic, because current drugs cannot eradicate latent infection with Toxoplasma gondii and can cause bone marrow toxicity. Because latent infection remains after treatment, relapse of infection is a problem in both infections in immunocompromised patients and in congenitally infected patients. To identify lead compounds for novel drugs against Toxoplasma...