Antimicrobial therapeutic plasma monitoring by applying PK/PD in burn patients
نویسندگان
چکیده
The aim of this chapter is to evaluate the contribution of antimicrobial therapeutic drug monitoring (TDM) to adjust dosing regimens in achieving control of infections using pharmacokinetics (PK) and pharmacodynamics (PD) to define the antimicrobial exposures that are necessary to maximise bactericidal activity and to inhibit bacterial growth. Robustness data exist for some antimicrobial agents, including the ratios of PK/PD parameters to the minimal inhibitory concentrations of bacteria that are associated with maximal antimicrobial effects (e.g., peak drug plasma concentration, Cmax:MIC ratio; area under the curve, AUC0-24:MIC ratio; and time interval required to maintain the minimum plasma drug concentration above the minimum inhibitory concentration, ΔT>MIC). The application of PK/PD tools for the effective control of severe infections must be considered for systemically administered antimicrobial agents that are prescribed to burn patients and other critically ill patients in the intensive care unit.
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