Oral treatment of trichomonal vaginitis with 2-acetylamino-5-nitrothiazole (tritheon).

Perl, Guttmacher, and Raggazoni (1956) reported that approximately one-third of patients with trichomonal vaginitis were cured after oral treatment with 2-acetylamino-5-nitrothiazole and the local application of an acid jelly. In our hands initial results seemed less satisfactory and it seemed that the little good that accrued might have been due to local therapy. For this reason, a small controlled trial was instituted, using volunteer patients who had trichomonads present in the vaginal smear, who had received no antitrichomonal treatment during the previous 6 weeks and who would be able to attend for frequent observation during treatment.