Ni-Catalyzed Enantioselective C-Acylation of α-Substituted Lactams.
نویسندگان
چکیده
A new strategy for catalytic enantioselective C-acylation to generate α-quaternary-substituted lactams is reported. Ni-catalyzed three-component coupling of lactam enolates, benzonitriles, and aryl halides produces β-imino lactams that then afford β-keto lactams by acid hydrolysis. Use of a readily available Mandyphos-type ligand and addition of LiBr enable the construction of quaternary stereocenters on α-substituted lactams to form β-keto lactams in up to 94% ee.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 138 29 شماره
صفحات -
تاریخ انتشار 2016