A Soluble Factor Released by CDSfCD57+ Lymphocytes From Bone Marrow Transplanted Patients Inhibits Cell-Mediated Cytolysis
نویسندگان
چکیده
We report a new inhibitory activity of CD8'CD57+ peripheral blood lymphocytes from allo-bone marrow transplant patients. Positively selected CD8TD57' lymphocytes act as potent inhibitors of allospecific cytolytic T lymphocyte and lymphokine activated killer cell cytolytic activities. These suppressor cells are mature T cells expressing the CD2,5,7, CD3-TcRap complex, and lack natural killer cell markers as well as cytolytic function. Their inhibitory activity on both
منابع مشابه
A soluble factor released by CD8+CD57+ lymphocytes from bone marrow transplanted patients inhibits cell-mediated cytolysis.
We report a new inhibitory activity of CD8+CD57+ peripheral blood lymphocytes from allo-bone marrow transplant patients. Positively selected CD8+CD57+ lymphocytes act as potent inhibitors of allospecific cytolytic T lymphocyte and lymphokine activated killer cell cytolytic activities. These suppressor cells are mature T cells expressing the CD2, 5, 7, CD3-TcR alpha beta complex, and lack natura...
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