CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation
نویسندگان
چکیده
D. F. McAuley,* G. F. Curley,* U. I. Hamid, J. G. Laffey, J. Abbott, D. H. McKenna, X. Fang, M. A. Matthay, and J. W. Lee Centre for Infection and Immunity, The Queen’s University of Belfast, Belfast, Northern Ireland; Department of Anestheisa, St. Michael’s Hospital, and the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Canada; Departments of Anesthesiology and Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California; and Molecular and Cellular Therapeutics, University of Minnesota, St. Paul, Minnesota
منابع مشابه
Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.
Recent studies have suggested that bone marrow-derived multipotent mesenchymal stem cells (MSCs) may have therapeutic applications in multiple clinical disorders including myocardial infarction, diabetes, sepsis, and hepatic and acute renal failure. Here, we tested the therapeutic capacity of human MSCs to restore alveolar epithelial fluid transport and lung fluid balance from acute lung injury...
متن کاملSelected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung.
Pulmonary edema is common in organ donors and lung transplant recipients. Therefore, we assessed the responsiveness of human donor lungs to pharmacological agents that stimulate clearance of alveolar edema. Organ donors whose lungs were rejected for transplantation were studied. After resection, transport (4 degrees C), and rewarming (37 degrees C) of lungs, alveolar fluid clearance was measure...
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Objective(s): Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic injuries. This work is focused on the administration of MSC to IRI-induce...
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Background Chronic allograft nephropathy(CAN) is one of the most common causes of chronic and end stage renal disease. It is defined with Mainly tubular atrophy and interstitial fibrosis and no evidence of any other etiology, or functional disorder that caused at least three months after transplantation . Control of risk factors (HTN,DM,HLP, …) and limiting usage of calcineurin inhibitors...
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238 February 2015 A CUTE respiratory distress syndrome (ARDS) is a major cause of acute respiratory failure in critically ill patients. Despite improvements in understanding the pathophysiology of ARDS, its mortality remains high.1,2 Current treatments rely on supportive measures, such as lung-protective ventilation, conservative fluid management, and prone positioning.3–5 No pharmacological th...
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