The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles.
نویسندگان
چکیده
The unprecedented application of unmodified aldehydes as nucleophilic donors in direct catalytic asymmetric Mannich-type reactions is disclosed in a full account. Our efforts in broadening the applicability of chiral pyrrolidine-based catalysts in direct asymmetric Mannich-type reactions led to the highly diastereo- and enantioselective and concise synthesis of functionalized alpha- and beta-amino acids, beta-lactams, and amino alcohols.
منابع مشابه
Direct asymmetric anti-Mannich-type reactions catalyzed by a designed amino acid.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 68 25 شماره
صفحات -
تاریخ انتشار 2003