One-pot, single-step deracemization of 2-hydroxyacids by tandem biocatalytic oxidation and reduction.

نویسندگان

  • Ya-Ping Xue
  • Yu-Guo Zheng
  • Ya-Qin Zhang
  • Jing-Lei Sun
  • Zhi-Qiang Liu
  • Yin-Chu Shen
چکیده

A facile and efficient one-pot, single-step method for deracemizing a broad range of 2-hydroxyacids to (R)-2-hydroxyacids was established by combination of resting cells of an (S)-hydroxyacid dehydrogenase-producing microorganism and an (R)-ketoacid reductase-producing microorganism.

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عنوان ژورنال:
  • Chemical communications

دوره 49 91  شماره 

صفحات  -

تاریخ انتشار 2013