Laboratory evaluation of controlled-release repellent formulations on human volunteers under three climatic regimens.

نویسندگان

  • R K Gupta
  • L C Rutledge
چکیده

Six controlled-release personal-use topical insect/arthropod repellent formulations of diethylmethylbenzamide (deet) were evaluated in an environmental chamber on volunteers for repellency against the mosquitoes Aedes aegypti and Ae. taeniorhynchus under three climatic regimens: basic variable high humidity (tropical environment), basic constant high humidity (forested and wet environment) and basic hot (hot-dry environment). The best protection under all the climatic regimens was provided by the Biotek formulation. In a tropical environment, some formulations induced more biting from mosquitoes than the concurrent untreated control in the late hours of the testing. Repellency was not directly related to the deet concentration in the various controlled-release repellent formulations.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Controlled-Release Low Density Effervescent Floating Matrix Tablets of Risperidone: Development, Optimization, in vitro-in vivo Evaluation in Healthy Human Volunteers and Determination of Dissolution Equivalency

The main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of Methocel® K15, Ethocel® standard 7FP premium, Eudragit ® RS100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. Risperidone floating tablets were formulated by wet granulati...

متن کامل

Design and Comparative Evaluation of In-vitro Drug Release, Pharmacokinetics and Gamma Scintigraphic Analysis of Controlled Release Tablets Using Novel pH Sensitive Starch and Modified Starchacrylate Graft Copolymer Matrices

The present investigation deals with the development of controlled release tablets of salbutamol sulphate using graft copolymers (St-g-PMMA and Ast-g-PMMA) of starch and acetylated starch. Drug excipient compatibility was spectroscopically analyzed via FT-IR, which confirmed no interaction between drug and other excipients. Formulations were evaluated for physical characteristics like hardness,...

متن کامل

Design and Comparative Evaluation of In-vitro Drug Release, Pharmacokinetics and Gamma Scintigraphic Analysis of Controlled Release Tablets Using Novel pH Sensitive Starch and Modified Starchacrylate Graft Copolymer Matrices

The present investigation deals with the development of controlled release tablets of salbutamol sulphate using graft copolymers (St-g-PMMA and Ast-g-PMMA) of starch and acetylated starch. Drug excipient compatibility was spectroscopically analyzed via FT-IR, which confirmed no interaction between drug and other excipients. Formulations were evaluated for physical characteristics like hardness,...

متن کامل

Twelve-hour duration testing of cream formulations of three repellents against Amblyomma americanum.

The repellent efficacies of the U.S. military repellent 33% N,N-diethyl-3-methylbenzamide (deet), 10% and 20% (1S, 2'S) 2-methylpiperidinyl-3-cyclohexene-1-carboxamide (SS220) and 10% and 20% 1-methyl-propyl-2-(hydroxyethyl)-1-piperidinecarboxylate (Bayrepel) cream formulations on human volunteers against the lone star tick Amblyomma americanum (L.) were evaluated in a simulated forest floor en...

متن کامل

Twelve-hour duration testing of cream formulations of three repellents against Amblyomma americanum

The repellent efficacies of the U.S. military repellent 33% N,N-diethy l-3-methylbenzamide (deet), 10% and 20% (1S, 2 ′ S) 2-methylpiperidinyl-3-cyclohexene 1-carboxamide (SS220) and 10% and 20% 1-methyl-propyl-2-(hydroxyethyl)-1-piperidinecarboxylate (Bayrepel) cream formulations on human volunteers against the lone star tick Amblyomma americanum (L.) were evaluated in a simulated forest floor...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of the American Mosquito Control Association

دوره 5 1  شماره 

صفحات  -

تاریخ انتشار 1989