Malaria-Induced B Cell Genomic Instability
نویسندگان
چکیده
Nussenzweig and colleagues evaluate genomic instability and germinal center derived lymphomagenesis in mice infected with Plasmodium to recreate some of the hallmark characteristics of Burkitt lymphoma, a form of cancer more common in parts of Africa where malaria is endemic.
منابع مشابه
Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma
Chronic infection with Plasmodium falciparum was epidemiologically associated with endemic Burkitt's lymphoma, a mature B cell cancer characterized by chromosome translocation between the c-myc oncogene and Igh, over 50 years ago. Whether infection promotes B cell lymphoma, and if so by which mechanism, remains unknown. To investigate the relationship between parasitic disease and lymphomagenes...
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ورودعنوان ژورنال:
- Cell
دوره 162 شماره
صفحات -
تاریخ انتشار 2015