Effect of altered intrathoracic pressure on renal hemodynamics, electrolyte excretion and water clearance.
نویسندگان
چکیده
Breathing against a continuous positive or negative pressure has been demonstrated to alter urine flow. Continuous positive pressure breathing is associated with a decrease in the rate of urine flow in dog (1) and man (2), whereas breathing against a constant negative pressure produces an increased rate of urine flow in the same species (1, 3). A decrease in urea clearance accompanies the antidiuresis of positive pressure breathing and suggests an altered rate of glomerular filtration (1). The diuresis of negative pressure breathing is not associated with marked changes in endogenous creatinine clearance or sodium and potassium excretion (1, 3). These alterations in the rate of urine flow have been attributed to changes in distribution of blood within the chest (1). Positive pressure breathing is associated with a displacement of blood from the thorax, and breathing against a negative pressure results in an increase in the intrathoracic blood volume. Henry, Gauer and Reeves postulated that these changes in urine flow are brought about through stretch receptors in the wall of the atria and greater vessels of the thorax (4), and demonstrated that the response of the dog to negative pressure breathing could be prevented by chilling of the vagus (5). These reports suggested that such a pathway involves also a humoral substance of antidiuretic nature. The study reported in this paper was designed to evaluate the role of renal hemodynamics and
منابع مشابه
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 38 5 شماره
صفحات -
تاریخ انتشار 1959