AB071. The molecular mechanism of acrosome formation and globozoospermia
نویسنده
چکیده
Sperm banking is an important option to maintain or induce the male fertilization even though under the era of in vitro fertilization. The medical indications for sperm banking are generally consisted of three categories. There are cases on planning the permanent contraception like vasectomy or cancer patients to be scheduled the chemotherapy or radiotherapy as first category, male infertile patients with severe oligozoospermia or artificially harvested sperm i.e., from MESA or TESE etc. for the artificial insemination with husband sperm as second category, and the therapeutic artificial insemination with donated sperm as third category. Of these three categories, the sperm donation programme accompanies various complicated practical, ethical and legal issues. Therefore, highly regulated statements are mandatory in order to secure safety and perfect practice for voluntary sperm donors and infertile couples both. In aspect of administrative structure of sperm bank, there are two types that are public based in the most of European countries and China, and commercially available in the USA. Additionally, each country has different standard guideline, regulation statement, act and law to control the sperm donation programmes. Nevertheless, we need a consensus document to operate the sperm bank with the standard guidelines to be well revised according to each country’s ethical perspectives as well as contemporary scientific evolution. This lecture will present the Korean experience in the sperm bank in comparison with different situation in various countries.
منابع مشابه
Lack of acrosome formation in mice lacking a Golgi protein, GOPC.
The acrosome is a unique organelle that plays an important role at the site of sperm-zona pellucida binding during the fertilization process, and is lost in globozoospermia, an inherited infertility syndrome in humans. Although the acrosome is known to be derived from the Golgi apparatus, molecular mechanisms underlying acrosome formation are largely unknown. Here we show that Golgi-associated ...
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© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2015;4(S1) www.amepc.org/tau PubMed, and also report some research progress of acrosome formation in our laboratory. Results: Acrosome formation can be divided into four stages: Golgi-phase, cap-phase, acrosome-phase and maturation-phase. In the past 10 years, with gene targeting technology, more than ten genes were...
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Globozoospermia is a common reproductive disorder that causes male infertility in humans, and the malformation or loss of acrosomes is the prominent feature of this disease. Although the acrosome is thought to be derived from the Golgi apparatus, the detailed molecular mechanisms remain unclear. GM130 is a cis-side localized Golgi matrix protein,whereas the physiological functions of this prote...
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Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety of processes, organelles and structures are involved in acrosome biogenesis including, trans-Golgi network (TGN), acroplaxome and cellular trafficking. This review a...
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