Novel strategy to identify MHC class II-promiscuous CD4+ peptides from tumor antigens for utilization in vaccination
نویسندگان
چکیده
Background Although cytotoxic CD8 T lymphocytes (CTL) were historically considered primary effectors of antitumor immunity, solely boosting CTL responses with CD8 vaccines in various tumor types has yielded unpredictable clinical results, possibly because CTLs function suboptimally without adequate CD4 T lymphocyte help. CD4 T-helper type 1 (Th1) cells secrete INF-g/TNF-a, inducing tumor senescence and apoptosis. As such, successful incorporation of CD4 epitopes into cancer vaccine construction and generation of durable antigen-specific CD4 immunity remains a challenge. Using the extracellular domain (ECD) of HER3 as a candidate “oncodriver” tumor antigen, we sought to identify immunogenic HER3 peptides that demonstrate Class II promiscuity and generate anti-HER3 CD4 immunity for inclusion in vaccine development.
منابع مشابه
Universal tumor-reactive helper peptides from telomerase as new tools for anticancer vaccination
Accumulating evidence demonstrates the importance of CD4+ T cells in antitumor immune responses. Identifying promiscuous MHC class II-binding peptides derived from relevant tumor-associated antigens that specifically target CD4+ helper T cells in vivo represent a powerful approach to fully exploit these cells for anticancer immunotherapy.
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