Catalytic antibodies to an S. aureus virulence factor 1 Constitutive Production of Catalytic Antibodies to a Staphylococcus aureus Virulence Factor and Effect of Infection*
نویسندگان
چکیده
1 To whom correspondence should be addressed: Sudhir Paul, Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas–Houston Medical School, 6431 Fannin, Houston, Texas 77030, USA, Tel.: 713-500-5347; Fax: 713-500-0574; E-mail: [email protected]; Or Eric L. Brown, Center for Infectious Diseases, University of Texas School of Public Health, 1200 Herman Pressler Drive, Houston, Texas 77030, USA, Tel.: 713-500-9355; Fax: 713-500-9359; E-mail: [email protected].
منابع مشابه
Constitutive production of catalytic antibodies to a Staphylococcus aureus virulence factor and effect of infection.
Antibodies that recognize microbial B lymphocyte superantigenic epitopes are produced constitutively with no requirement for adaptive immune maturation. We report cleavage of the Staphylococcus aureus virulence factor extracellular fibrinogen-binding protein (Efb) by catalytic antibodies produced with no exposure to the bacterium and reduction of the catalytic antibody activity following infect...
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