CLINICAL TRIALS AND OBSERVATIONS Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

1University of New Mexico Cancer Center and Departments of Pathology and Internal Medicine, University of New Mexico, Albuquerque; 2Children’s Oncology Group, Arcadia, CA; 3Department of Pathology, St Jude Children’s Research Hospital, Memphis, TN; 4Department of Genetics, University of Alabama, Birmingham; 5Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN; 6College of Public Health, University of Georgia, Athens; 7Cancer Therapy Evaluation Program, Pediatric Oncology, National Cancer Institute, Bethesda, MD; 8Departments of Pediatrics, Hematology and Oncology, and Cancer Center, New York University Medical Center, NY; 9Children’s Oncology Group Statistics & Data Center and Department of Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville; 10Cook Children’s Medical Center, Forth Worth, TX; 11Department of Pediatrics, Hematology, Oncology and Transplantation, Medical College of Wisconsin, Milwaukee; 12Department of Hematology-Oncology, Children’s National Medical Center, Washington, DC; and 13Children’s Hospital, Department of Pediatrics and University of Colorado Cancer Center, University of Colorado Denver School of Medicine, Aurora