Amine and Titanium (IV) Chloride, Boron (III) Chloride or Zirconium (IV) Chloride-Promoted Baylis-Hillman Reactions
نویسندگان
چکیده
The Baylis-Hillman reactions of various aryl aldehydes with methyl vinyl ketone at temperatures below -20C using Lewis acids such as titanium (IV) chloride, boron (III) chloride or zirconium (IV) chloride in the presence of a catalytic amount of selected amines used as a Lewis bases afford the chlorinated compounds 1 as the major product in very high yields. Acrylonitrile can also undergo the same reaction to give the corresponding chlorinated product in moderate yield. A plausible reaction mechanism is proposed. However, if the reaction was carried out at room temperature (ca. 20C), then the Z-configuration of the elimination product 3, derived from 1, was formed as the major product.
منابع مشابه
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