NMR study of gluconeogenesis and TCA cycle flux in humans
نویسندگان
چکیده
JOHN G. JONES,1 MICHAEL A. SOLOMON,2 SUZANNE M. COLE,3 A. DEAN SHERRY,1,3 AND CRAIG R. MALLOY1,2 1Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235; 2Department of Internal Medicine, University of Texas Southwestern Medical Center and Department of Veterans Affairs Medical Center, Dallas 75216; and 3Department of Chemistry, University of Dallas, Richardson, Texas 75083
منابع مشابه
An integrated (2)H and (13)C NMR study of gluconeogenesis and TCA cycle flux in humans.
Hepatic glucose synthesis from glycogen, glycerol, and the tricarboxylic acid (TCA) cycle was measured in five overnight-fasted subjects by (1)H, (2)H, and (13)C NMR analysis of blood glucose, urinary acetaminophen glucuronide, and urinary phenylacetylglutamine after administration of [1,6-(13)C(2)]glucose, (2)H(2)O, and [U-(13)C(3)]propionate. This combination of tracers allows three separate ...
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