Three-dimensional nanoscale molecular imaging by extreme ultraviolet laser ablation mass spectrometry
نویسندگان
چکیده
Analytical probes capable of mapping molecular composition at the nanoscale are of critical importance to materials research, biology and medicine. Mass spectral imaging makes it possible to visualize the spatial organization of multiple molecular components at a sample's surface. However, it is challenging for mass spectral imaging to map molecular composition in three dimensions (3D) with submicron resolution. Here we describe a mass spectral imaging method that exploits the high 3D localization of absorbed extreme ultraviolet laser light and its fundamentally distinct interaction with matter to determine molecular composition from a volume as small as 50 zl in a single laser shot. Molecular imaging with a lateral resolution of 75 nm and a depth resolution of 20 nm is demonstrated. These results open opportunities to visualize chemical composition and chemical changes in 3D at the nanoscale.
منابع مشابه
Characterization of extreme ultraviolet laser ablation mass spectrometry for actinide trace analysis and nanoscale isotopic imaging
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(54) Three-dimensional Molecular Imaging by Infrared Laser Ablation Electrospray Ionization Mass Spectrometry Dreidimensionale Molekulare Bildgebung Mittels Infrarot-laserablation- Elektrospray-ionisation-massenspektrometri E Imagerie Moleculaire Tridimensionnelle Par Spectrometrie De Masse
(72) Inventors: • VERTES, Akos Reston VA 20190 (US) • NEMES, Peter Silver Spring MD 20906 (US) • PETER NEMES ET AL: "Ambient Molecular Imaging and Depth Profiling of Live Tissue by Infrared Laser Ablation Electrospray Ionization Mass Spectrometry",ANALYTICAL CHEMISTRY, vol. 80, no. 12, 1 June 2008 (2008.06-01), pages 4575-4582, XP55024857, ISSN: 0003-2700, 001: 10.1021/ac8004082 • "Generation o...
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