Micronuclei (Oral Cancer Biomarker) Study in Buccal Mucosal Cell with Betel Quid Chewers among Indian Population
نویسنده
چکیده
Oral cancer is most common cancer in males and third most common in females, the main causative agent being use of chewing betel quid (BQ). The micronucleus (MN) assay in exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans. Micronuclei (MN) have been proposed as good biomarker to assess cytogenetic damage. MN formation has been observed in cancer and pre-cancerous lesions of the oral cavity of betel quid chewers. In this present study cases were screened from Camp in Eastern India, Camp in North East India, Subjects attending Oral &Maxillofacial and ENT department of Ramakrishna Mission Seva Pratishthan(RKMSP), Kolkata and Onco surgery department, ESI hospital, Sealdah, Kolkata. Micronuclei percentage are higher in oral cancer cases than normal.
منابع مشابه
Induction of micronuclei in buccal mucosa on chewing a mixture of betel leaf, areca nut and tobacco.
Betel quid containing areca nut and chewing tobacco is used in many parts of India. In this study we evaluated the micronuclei (MN) in buccal mucosa of healthy individuals from southern India, who were regularly chewing a mixture of betel leaf, areca nut and tobacco. A total of 44 subjects were examined. The study population included 15 chewers, 14 chewers with smoking habit and 15 controls wit...
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