Anti-TNF Treatment in Inflammatory Bowel Disease
نویسنده
چکیده
Crohn’s disease and ulcerative colitis are chronic inflammatory disorders of the gastrointestinal tract. Although the primary etiological defect stil remains unknown, in the last decade impotant progress has been made concerning the immunological basis of the disease. Genetic, environmental and microbial factors result in repeated activation of mucosal immune response. Tumor necrosis factor alpha (TNF-alpha) is one of the central cytokines in the underlying pathogenesis of mucosal inflammation in inflammatory bowel disease (IBD) and has been the primary target of biologic therapies.
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