Mediastinoscopy after negative endoscopic mediastinal nodal staging: can it be omitted?

References 1 World Health Organization. Companion Handbook to the WHO Guidelines for Programmatic Management of Drug Resistant Tuberculosis. WHO/HTM/TB/2014.11. Geneva, WHO, 2014. 2 Cox HS, Furin J, Mitnick CD, et al. The need to accelerate access to new drugs for multidrug-resistant tuberculosis. Bull World Health Organ 2015; 93: 491–497. 3 Isaakidis P, Cox HS, Varghese B, et al. Ambulatory multi-drug resistant tuberculosis treatment outcomes in a cohort of HIV-infected patients in a slum setting in Mumbai, India. PLoS One 2011; 6: e28066. 4 Cox HS, Hughes JA, Daniels J, et al. Community-based treatment of drug-resistant tuberculosis in Khayelitsha, South Africa. Int J Tuberc Lung Dis 2014; 18: 441–448. 5 Dheda K, Shean K, Zumla A, et al. Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study. Lancet 2010; 375: 1798–1807. 6 Cegielski JP, Dalton T, Yagui M, et al. Extensive drug resistance acquired during treatment of multidrug-resistant tuberculosis. Clin Infect Dis 2014; 59: 1049. 7 Pietersen E, Ignatius E, Streicher E, et al. Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: a cohort study. The Lancet 2014; 383: 1230–1239. 8 Zhang L, Pang Y, Yu X, et al. Linezolid in the treatment of extensively drug-resistant tuberculosis. Infection 2014; 42: 705–711. 9 Lee M, Cho SN, Barry CE III, et al. Linezolid for XDR-TB – final study outcomes. N Engl J Med 2015; 373: 290–291. 10 Hillemann D, Rusch-Gerdes S, Richter E. In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants. Antimicrob Agents Chemother 2008; 52: 800–801. 11 Robijns K, Harteveld AR, Greijdanus B, et al. An interlaboratory quality control programme for the measurement of tuberculosis drugs. Eur Respir J 2015; 46: 268–271. 12 Daskapan A, de Lange WC, Akkerman OW, et al. The role of therapeutic drug monitoring in individualised drug dosage and exposure measurement in tuberculosis and HIV co-infection. Eur Respir J 2015; 45: 569–571.