CALL FOR PAPERS Angiogenesis in Health and Disease Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation
نویسندگان
چکیده
Mark J. Post, Kaori Sato, Masahiro Murakami, Jialin Bao, Daniela Tirziu, Justin D. Pearlman, and Michael Simons Angiogenesis Research Center and Section of Cardiology, Dartmouth Medical School, Lebanon, New Hampshire; Beth Israel Deaconess Medical Center, Boston, Massachusetts; and Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
منابع مشابه
Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation.
Angiogenic therapy with individual growth factors or "master switch" genes is being evaluated for treatment of advanced coronary artery disease. In this study, we investigated the efficacy and mechanism of PR39, a gene capable of activating VEGF and fibroblast growth factor (FGF)-2-dependent pathways. PR39 enhances hypoxia-inducible factor-1alpha (HIF-1alpha)-dependent gene expression by select...
متن کاملMolecular Study of Vascular Endothelial Growth Factor Gene in Iranian Patients after Myocardial Infarction
Background: Stimulation of collateral artery growth (arteriogenesis) and/or capillary network growth (angiogenesis) would be beneficial to the patients with myocardial infarction. To understand the central role of vascular endothelial growth factor (VEGF) in biological angiogenesis, we performed molecular analysis of the VEGF gene in patients afflicted with acute myocardial infarction (AMI). Me...
متن کاملEffects of Taurine, Sestrin 2 and Phyllanthin on coronary artery diseases
Heart failure is a growing epidemic in the worldwide. Atherosclerosis is a major mechanism of cardiovascular disease including myocardial infarction and peripheral arterial disease. Moreover, it causes many diseases and deaths around the world. Atherosclerosis, like coronary artery disease (CAD), is associated with inflammation and oxidative stress. The current article has been collected the s...
متن کاملEfficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia.
BACKGROUND Therapeutic angiogenesis in ischemic myocardium has been shown to be a feasible and effective strategy to improve regional blood flow and myocardial function. However, the optimal mode of growth factor administration still needs to be established. METHODS Using a pig model of chronic myocardial ischemia, we evaluated the efficacy of intravenous and intracoronary infusion of FGF-2 a...
متن کاملCollateral Circulation in Chronic Total Occlusions - An Interventional Perspective
Human coronary collaterals are inter-coronary communications that are believed to be present from birth. In the presence of chronic total occlusions, recruitment of flow via these collateral anastomoses to the arterial segment distal to occlusion provide an alternative source of blood flow to the myocardial segment at risk. This mitigates the ischemic injury. Clinical outcome of coronary occlus...
متن کامل