Sedimentation, diffusion, and molecular weight of a mucoprotein from human plasma.

Investigations by some of us (l-3) have been concerned with the demonstration by electrophoresis of mucoproteins in normal and pathological sera. It was found that at least three electrophoretic components were present in crude mucoprotein fractions. More recently, the isolation in electrophoretically homogeneous form of the major mucoprotein component of normal human plasma has been described, and chemical and electrophoretic characterization of this substance was presented (4). In this communication, further studies of the physical properties of this mucoprotein will be reported.