The Binding of Abrin and Ricin by Ehrlich Ascites Tumor Cells1
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چکیده
teins on the tumor cells was shown to be specific, pH de pendent, and concentration dependent. Native ricin, abrin, D-galactose, and its sterically related saccharides inhibit this specific binding, while concanavalin A, bovine serum albumin, heat-denatured abrin or ricin, and other sac charides do not. In the presence of D-galactose, the inhibi tion of protein biosynthesis by ricin does not occur in vitro.
منابع مشابه
The binding of abrin and ricin by Ehrlich ascites tumor cells.
teins on the tumor cells was shown to be specific, pH de pendent, and concentration dependent. Native ricin, abrin, D-galactose, and its sterically related saccharides inhibit this specific binding, while concanavalin A, bovine serum albumin, heat-denatured abrin or ricin, and other sac charides do not. In the presence of D-galactose, the inhibi tion of protein biosynthesis by ricin does not oc...
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The mechanism of penetration of the toxic plant proteins abrin and ricin into Ehrlich ascites cells has been studied by measuring, under different experimental conditions, the lag occurring from the time the cells have been incubated with the toxins until protein synthesis in the cells is inhibited. When Ehrllch ascites cells were incubated with abrln or ricin at 37”, a lag time of at least 30 ...
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