Pathogenesis of obliterative bronchiolitis in rat heterotopic tracheal allografts An experimental approach to chronic lung allograft rejection
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منابع مشابه
TIMP-1 Deficiency Abrogates Obliterative Airway Disease after Heterotopic Tracheal Transplantation
Obliterative bronchiolitis (OB) is a major cause of allograft dysfunction after lung transplantation and is thought to result from immunologically mediated airway epithelial destruction and luminal fibrosis. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been implicated in the regulation of lung inflammation, airway epithelial repair and extracellular ...
متن کاملThe heterotopic tracheal allograft as an animal model of obliterative bronchiolitis
Heterotopic tracheal allografts in small rodents have been shown to share many characteristics with the development of obliterative bronchiolitis (OB) in the clinic and therefore provide a suitable animal model for the study of OB. The model facilitates the examination of the pathogenesis of the disease and the elucidation of the cellular and molecular mechanisms involved in its development. Th...
متن کاملIdentification and Inhibition of Specific Pathways Leading to Transplant Obliterative Bronchiolitis -an Experimental Approach in the Rat
21 5.2. Platelet-derived growth factor 23 6. CMV infection in lung transplantion 24 6.1. Human CMV 24 6.2. Rat CMV 25 6.3. Role of CMV infection in alloimmune activation 25 6.4. Treatment of CMV infection 27 7. Heterotopic tracheal transplantation as a model for OB 29 AIMS OF THE STUDY 30 METHODS 31 1. Heterotopic tracheal transplantations 31 2. Rat CMV infection 31 3. Drug regimens 32 4. Histo...
متن کاملTissue inhibitor of metalloproteinase-1 deficiency abrogates obliterative airway disease after heterotopic tracheal transplantation.
Obliterative bronchiolitis (OB) is a major cause of allograft dysfunction after lung transplantation and is thought to result from immunologically mediated airway epithelial destruction and luminal fibrosis. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been implicated in the regulation of lung inflammation, airway epithelial repair, and extracellular...
متن کاملEarly growth response gene-1 promotes airway allograft rejection.
Chronic airway rejection, characterized by lymphocytic bronchitis, epithelial cell damage, and obliterative bronchiolitis (OB), limits long-term survival after lung transplantation. The transcription factor early growth response gene-1 (Egr-1) induces diverse inflammatory mediators, some involved in OB pathogenesis. An orthotopic mouse tracheal transplant model was used to determine whether Egr...
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