Enteric fever--a changing sensitivity pattern, clinical profile and outcome.

With the changing pattern of bacterial infection and their sensitivity trends, pediatricians throughout the world are facing a challenging problem in day to day practice(l). The recent upsurge in multidrug resistant S. typhi infection, has made the treatment of enteric fever a difficult and controversial problem(l,2). The second line therapy suggested for drug resistant typhoid fever has also proven ineffective in managing such cases in recent past(2-6). A lot of work has already been done on MDRST infection. However, our study is based on large data of positive cases of S. typhi with changing sensitivity patterns. ' Material and Methods