Effect of a-Interferon Therapy on Bone Marrow Fibrosis in Hairy Cell Leukemia
نویسندگان
چکیده
Iliac crest trephine biopsy specimens from 1 6 patients treated with recombinant a2-interferon (a-IFN) for hairy cell leukemia (HCL) were examined for reticulin and colIagen content. These data were compared with the hairy cell index (HCI). the proportion of hairy cells to the overall cellularity of the bone marrow. Specimens were studied immediately before a-IFN therapy. at 6-month intervals during. and in six patients 6 months after cessation of therapy. All patients presented with increased bone marrow fibrosis ranging from focally increased reticulin to a diffuse increase in both reticulin and collagen content. This fibrosis was observed to decrease during a-IFN therapy
منابع مشابه
Effect of alpha-interferon therapy on bone marrow fibrosis in hairy cell leukemia.
Iliac crest trephine biopsy specimens from 16 patients treated with recombinant alpha 2-interferon (alpha-IFN) for hairy cell leukemia (HCL) were examined for reticulin and collagen content. These data were compared with the hairy cell index (HCl), the proportion of hairy cells to the overall cellularity of the bone marrow. Specimens were studied immediately before alpha-IFN therapy, at 6-month...
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