Gut Microbiota and Type 1 Diabetes.

Relationship between gut microbiota and type 2 diabetes

Diabetes is the most common endocrine disease following the spread of metabolic diseases worldwide. Diabetes is also the fifth leading cause of death in the world. Patients with type 2 diabetes account for about 90% of people with diabetes. Studies over the past years have shown a significant association between intestinal microbiota, intestinal dysbiosis, and metabolic syndrome. Changes in the...

Gut Microbiota and Neuropsychiatric Disorders

Gut microbiota: Its role in diabetes and obesity

Neil Munro is Visiting Professor in Primary Care Diabetes, Department of Clinical and Experimental Medicine, University of Surrey. The gut microbiota is a community of microogranisms that live in the gut and intestinal tract. The microbiota consists of bacteria, archaea and eukarya, as well as viruses, but is predominantly populated by anaerobic bacteria. Relationships between gut microbiota co...

Clinical application of gut microbiota metabolites: A novel opportunity in personalized medicine

Nowadays, metabolomics studies are performed with different approaches to identify biomarkers, clarify the underlying mechanisms of diseases and achieve novel treatment strategies. In this context, gut microbiota-derived metabolites are known as one of the most important mediators of gut microbiota effects on human health and various diseases. Due to the inefficiency of conventional therapies i...

The Gut Microbiota Modulates Glycaemic Control and Serum Metabolite Profiles in Non-Obese Diabetic Mice

Islet autoimmunity in children who later progress to type 1 diabetes is preceded by dysregulated serum metabolite profiles, but the origin of these metabolic changes is unknown. The gut microbiota affects host metabolism and changes in its composition contribute to several immune-mediated diseases; however, it is not known whether the gut microbiota is involved in the early metabolic disturbanc...

Th17 Cells in Type 1 Diabetes: Role in the Pathogenesis and Regulation by Gut Microbiome

Type 1 diabetes (T1D) is an autoimmune disease which is characterized by progressive destruction of insulin producing pancreatic islet β cells. The risk of developing T1D is determined by both genetic and environmental factors. A growing body of evidence supports an important role of T helper type 17 (Th17) cells along with impaired T regulatory (Treg) cells in the development of T1D in animal ...