B Cells Directly Tolerize CD 8 1 T Cells
نویسندگان
چکیده
From the * Immunology Division, The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia; ‡ The Cooperative Research Centre for Vaccine Technology at the Queensland Institute of Medical Research, The Royal Brisbane Hospital, Herston, Queensland 4029, Australia; and the § Department of Pathology and Immunology, Monash Medical School, Prahran, Victoria 3181, Australia
منابع مشابه
B Cells Directly Tolerize CD8+ T Cells
This report investigates the response of CD8(+) T cells to antigens presented by B cells. When C57BL/6 mice were injected with syngeneic B cells coated with the Kb-restricted ovalbumin (OVA) determinant OVA257-264, OVA-specific cytotoxic T lymphocyte (CTL) tolerance was observed. To investigate the mechanism of tolerance induction, in vitro-activated CD8(+) T cells from the Kb-restricted, OVA-s...
متن کاملof April 16 , 2017 . This information is current as through PDL - 1 Dendritic Cells and Cross - Tolerize T Cells Monocytes
متن کامل
Transcriptional targeting of B cells for induction of peripheral CD8 T cell tolerance.
Several mechanisms are in place to neutralize autoimmune CD8 T cells by tolerance induction. Developing self-specific CD8 T cells are eliminated in the thymus by Ag-presenting epithelial and dendritic cells (DCs). However, CD8 T cells escaping thymic central tolerance can also be inactivated by tolerance mechanisms in peripheral organs. In contrast to DCs, the role of B cells in generating CD8 ...
متن کامل