Neuro Forum The basis of orientation decoding in human primary visual cortex: fine- or coarse-scale biases?

Maloney RT. The basis of orientation decoding in human primary visual cortex: fineor coarse-scale biases? J Neurophysiol 113: 1–3, 2015. First published May 28, 2014; doi:10.1152/jn.00196.2014.—Orientation signals in human primary visual cortex (V1) can be reliably decoded from the multivariate pattern of activity as measured with functional magnetic resonance imaging (fMRI). The precise underlying source of these decoded signals (whether by orientation biases at a fine or coarse scale in cortex) remains a matter of some controversy, however. Freeman and colleagues (J Neurosci 33: 19695–19703, 2013) recently showed that the accuracy of decoding of spiral patterns in V1 can be predicted by a voxel’s preferred spatial position (the population receptive field) and its coarse orientation preference, suggesting that coarse-scale biases are sufficient for orientation decoding. Whether they are also necessary for decoding remains an open question, and one with implications for the broader interpretation of multivariate decoding results in fMRI studies.