Oecd Guideline for the Testing of Chemicals

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1. OECD Guidelines are periodically reviewed in the light of scientific progress, changing regulatory needs, and animal welfare considerations. The original acute inhalation Test Guideline 403 (TG 403) was adopted in 1981 (1). This revised TG 403 has been designed to be more flexible, to reduce animal usage, and to fulfil regulatory needs. The revised TG 403 features two study types: a Traditional LC50 protocol and a Concentration × Time (C×t) protocol. Primary features of this Guideline are the ability to provide a concentration-response relationship ranging from non-lethal to lethal outcomes in order to derive a median lethal concentration (e.g., LC50), non-lethal threshold concentration (e.g., LC01), and slope, and to identify possible gender sensitivity. The C×t protocol should be used when there is a specific regulatory or scientific need that calls for the testing of animals over multiple time durations, such as for purposes of emergency response planning (e.g., deriving AEGL, ERPG, or AETL values, or land-use planning).

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تاریخ انتشار 2008