A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerisation of poised BAX
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چکیده
Thank you for submitting your manuscript for consideration by the EMBO Journal. It has now been seen by two referees whose comments are shown below. We share the referees' interest in this manuscript, but also felt at the editorial level that the dataset could be developed realistically to allow more general as well as more mechanistically developed conclusions. I outline below key points raised by the referees. I apologize for the atypically slow reviewing process due to some delays at the referee and unfortunately also at the editorial level due to high submission volumes during the main conference and holiday season.
منابع مشابه
A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX
The cellular response to p53 activation varies greatly in a stimulus- and cell type-specific manner. Dissecting the molecular mechanisms defining these cell fate choices will assist the development of effective p53-based cancer therapies and also illuminate fundamental processes by which gene networks control cellular behaviour. Using an experimental system wherein stimulus-specific p53 respons...
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