HLA-A, -B, -DRB1 alleles and haplotypes frequencies in Moroccan patients with leukemia Fréquences des allèles et des haplotypes HLA-A, -B et -DRB1 chez des patients marocains atteints de leucémie

نویسندگان

  • Maria Kabbaj
  • Mounia Oudghiri
  • Abdellah Naya
  • Hamid Naamane
  • Joumana El Turk
  • Siham Bennani
  • Mohamed Hassar
چکیده

Maria Kabbaj Mounia Oudghiri Abdellah Naya Hamid Naamane Joumana El Turk Siham Bennani Mohamed Hassar 1 Laboratoire d’immunohistocompatibilité, Institut Pasteur, Casablanca, Maroc 2 Laboratoire de physiologie et de génétique moléculaire, Département de biologie, Faculté des Sciences Ain Chock, Université Hassan II, Casablanca, Maroc 3 Laboratoire de microbiologie et de biologie moléculaire, Centre national pour la recherche scientifique et technique, Rabat, Maroc

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HLA-A, -B, -DRB1 alleles and haplotypes frequencies in Moroccan patients with leukemia.

Previous studies have demonstrated some significant differences in HLA allele frequencies in leukemic patients and normal subjects. In Moroccan leukemic patients, the frequency of HLA alleles has not already been determined. We have analyzed HLA class I and class II alleles and haplotypes in 62 Moroccan leukemic patients and 98 unrelated normal subjects using PCR-SSO method. Significant positiv...

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Background: The Human Leukocyte Antigen (HLA) is the most polymorphic region in human genome. Moreover, HLA haplotype frequencies are largely used in transplantation, the treatment of autoimmune diseases, and population-based studies. The present study aimed to determine HLA-A, -B, -DR alleles and haplotype frequencies in 88 unrelated donors of Iranian Gilak ethnic group, by Polymerase Chain Re...

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  Background and Objective: The outcome of hepatitis B virus (HBV) infection may be influenced by host factors like Human Leukocyte Antigen (HLA). We have investigated HLA-A and DRB1 alleles in patients with persistent hepatitis B infection compared to subjects who had spontaneously recovered from HBV infection. To complete the findings of this study we performed another survey in certain HLA ...

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تاریخ انتشار 2010