1 2 In - Depth Profiling of the LiaR Response of Bacillus subtilis
نویسندگان
چکیده
7 8 Department Biology I, Ludwig-Maximilians-University Munich, Germany; Department of General 9 Microbiology, Georg-August-University Göttingen, Germany; Interfaculty Institute for Genetics and 10 Functional Genomics, Department for Functional Genomics, Ernst-Moritz-Arndt-University 11 Greifswald, Germany; Department of Microbiology, Free University Berlin, Germany; Department of 12 Microbial Physiology, Ernst-Moritz-Arndt-University Greifswald, Germany 13 14 Present affiliation for FK: Department of Microbiology and Immunology, University of Otago, 15 Dunedin, New Zealand; present address for JK: Department of Biochemistry, Molecular Biology and 16 Cell Biology, Northwestern University, Evanston IL, USA 17 18 19 Running title: LiaR response of Bacillus subtilis 20 21
منابع مشابه
In-depth profiling of the LiaR response of Bacillus subtilis.
The Lia system, a cell envelope stress response module of Bacillus subtilis, is comprised of the LiaRS two-component system and a membrane-anchored inhibitor protein, LiaF. It is highly conserved in the Firmicutes bacteria, and all orthologs investigated so far are activated by cell wall antibiotics. In response to envelope stress, the systems in Firmicutes cocci induce the expression of a numb...
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The regulatory network of the cell envelope stress response in Bacillus subtilis involves both extracytoplasmic function sigma-factors and two-component signal transducing systems. One such system, LiaRS, responds to cell wall antibiotics that interfere with the undecaprenol cycle and to perturbation of the cytoplasmic membrane. It is encoded by the last two genes of the liaIHGFSR locus. Here, ...
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