(−)-Complanine, an inflammatory substance of marine fireworm: a synthetic study
نویسندگان
چکیده
The synthesis of (-)-complanine, an inflammatory substance of Eurythoe complanata, was accomplished by a "chiral synthon" approach. The absolute configuration of this molecule was determined to be R.
منابع مشابه
Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata.
The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammoniu...
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A route is described for the enantioselective synthesis of (R)-(-)-complanine, a marine natural product isolated from Eurythoe complanata, and known to be a causative agent in inflammation. An organocatalytic, asymmetric oxyamination of a homoconjugated all-Z-dienal intermediate provides versatile and efficient access to the natural product.
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