EGFR in Limbo
نویسندگان
چکیده
The epidermal growth factor receptor (EGFR) is normally activated by ligand-induced dimerization. Oncogenic mutations in EGFR promote activation in a largely ligand-independent manner. Shan et al. uncover a partially disordered state of EGFR kinase, providing evidence that oncogenic mutations counteract this intrinsic structural instability to promote dimerization and aberrant activation.
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ورودعنوان ژورنال:
- Cell
دوره 149 شماره
صفحات -
تاریخ انتشار 2012