Successful treatment of intraocularly invasive conjunctival squamous cell carcinoma with proton beam therapy.

Due to an increase in UV light exposure, conjunctival squamous cell carcinoma has become increasingly more prevalent throughout the world. However, primary intraocular invasion from conjunctival squamous cell carcinoma still remains rare and is therefore often misdiagnosed. Larger, more aggressive lesions that invade the eye are frequently not amenable to standard excision and cryotherapy. For the treatment of such lesions, most authors advocate enucleation or exenteration if there is evidence of orbital invasion. The present case suggests that proton beam therapy may be a reasonable alternative to enucleation for the treatment of squamous cell carcinoma with intraocular invasion. To our knowledge, this is the first report of the treatment of invasive conjunctival squamous cell carcinoma using proton beam therapy.