Differential Echocardiographic Response to Cardiac Resynchronization Therapy and Clinical Outcomes According to QRS Morphology and QRS Duration
نویسندگان
چکیده
Results A total of 496 patients were included in the study; 216 (43.5%) had LBBB and a QRSd 150 ms, 85 (17.1%) had LBBB and QRSd 150 ms, 92 (18.5%) had non-LBBB and a QRSd 150 ms, and 103 (20.8%) had nonLBBB and QRSd 150 ms. Echocardiographic response (change in ejection fraction) was better in patients with LBBB and QRSd 150 ms (12 12%) than in those with LBBB and QRSd 150 ms (8 10%), non-LBBB and QRSd 150 ms (5 9%), and non-LBBB and QRSd 150 ms (3 11%) (p 0.0001). In a multivariate stepwise model with change in ejection fraction as the dependent variable, the presented classification was the most important independent variable (p 0.0003). Long-term survival was better in LBBB patients with QRSd 150 ms (p 0.02), but this difference was not significant after adjustment for other baseline characteristics (p 0.15).
منابع مشابه
Differential response to cardiac resynchronization therapy and clinical outcomes according to QRS morphology and QRS duration.
OBJECTIVES The goal of this study was to examine the relative impact of QRS morphology and duration in echocardiographic responses to cardiac resynchronization therapy (CRT) and clinical outcomes. BACKGROUND At least one-third of all patients treated with CRT fail to derive benefit. Patients without left bundle branch block (LBBB) or patients with smaller QRS duration (QRSd) respond less or n...
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