toxicity due to reverse Na + - Ca 2 + exchange contributes to degeneration of 1 neurites of DRG neurons induced by a neuropathy - associated Nav 1 . 7 mutation
نویسندگان
چکیده
Dept. of Neurology, Yale University School of Medicine, New Haven, CT; 6 Center for Neuroscience and Regeneration Research, 7 Veterans Affairs Connecticut Healthcare System, West Haven, CT; 8 Department of Neurology, University Medical Center Maastricht, Maastricht, the Netherlands; 9 Department of Neurology, Spaarne Hospital, Hoofddorp, the Netherlands 10 Neuroalgology Unit IRCCS Foundation "Carlo Besta" Neurological Institute 11 Via Celoria, 11 20133 Milan, Italy 12 13 Running title: Neuropathy-associated Nav1.7 mutation promotes axon degeneration 14 15 *contributed equally to manuscript 16
منابع مشابه
Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation.
Gain-of-function missense mutations in voltage-gated sodium channel Nav1.7 have been linked to small-fiber neuropathy, which is characterized by burning pain, dysautonomia and a loss of intraepidermal nerve fibers. However, the mechanistic cascades linking Nav1.7 mutations to axonal degeneration are incompletely understood. The G856D mutation in Nav1.7 produces robust changes in channel biophys...
متن کاملCa toxicity due to reverse Na /Ca exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation
M. Estacion,* B. P. S Vohra,* S. Liu, J. Hoeijmakers, C. G. Faber, I. S. J. Merkies, G. Lauria, J. A. Black, and S. G. Waxman Department of Neurology, Yale University School of Medicine, New Haven, Connecticut; Center for Neuroscience and Regeneration Research, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut; Department of Neurology, University Medical Center Maastricht,...
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