High Production Rates Sustain In Vivo Levels of PD-1 Simian Immunodeficiency Virus-Specific CD8 T Cells in the Face of Rapid Clearance
نویسندگان
چکیده
Constantinos Petrovas, Takuya Yamamoto, David A. Price, Srinivas S. Rao, Nichole R. Klatt, Jason M. Brenchley, Daniel C. Douek, Emma Gostick, Bastian R. Angermann, Zvi Grossman, Derek C. Macallan, Martin Meier-Schellersheim, Richard A. Koup Immunology Laboratory, Human Immunology Section, Laboratory of Animal Medicine, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA; Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA; Program in Systems Immunology and Infectious Disease Modeling, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA; Tel Aviv University School of Medicine, Tel Aviv, Israel; Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA; Infection and Immunity Research Centre, Division of Clinical Sciences, St. George’s Hospital, University of London, London, United Kingdom
منابع مشابه
High Production Rates Sustain In Vivo Levels of PD-1high Simian Immunodeficiency Virus-Specific CD8 T Cells in the Face of Rapid Clearance
Programmed Death 1 (PD-1) expression by human/simian immunodeficiency virus (HIV/SIV)-specific CD8 T cells has been associated with defective cytokine production and reduced in vitro proliferation capacity. However, the cellular mechanisms that sustain PD-1(high) virus-specific CD8 T cell responses during chronic infection are unknown. Here, we show that the PD-1(high) phenotype is associated w...
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