A Monkey Model for Epstein Barr Virus-associated Lymphomagenesis in Human Acquired Immunodeficiency Syndrome
نویسندگان
چکیده
From the "Department of Pathology, University of Innsbruck, A-6020 Austria; the ~lmmunopathology Laboratory, Karolinska Institute, S-I0401 Stockholm, Sweden; the SDepartment of Immunology, National Bacteriological Laboratory, S-10521 Stockholm, Sweden; the IIDepartment of Internal Medicine, University of Innsbruck, A-6020 Austria; the 82 of Virology, National Bacteriological Laboratory, S-10521 Stockholm, Sweden; and the **Department of Virology, Karolinska Institute, S-I0401 Stockholm, Sweden
منابع مشابه
A monkey model for Epstein Barr virus-associated lymphomagenesis in human acquired immunodeficiency syndrome [published erratum appears in J Exp Med 1992 Aug 1;176(2):following 634]
High-grade malignant nonHodgkin's lymphomas--five lymphoblastic, three pleomorphic, and two immunoblastic--developed in 10/25 cynomolgus monkeys (Macaca fascicularis) followed for up to 746 d after infection with simian immunodeficiency virus, strain SIVsm. These lymphomas were shown to be associated with an Epstein-Barr (EB)-like cynomolgus B-lymphotropic herpesvirus (CBLV) by electron microsc...
متن کاملDistribution of Epstein-Barr Virus and Human Herpesvirus 8 Co-Infections among Human Immunodeficiency Virus -1 Positive Patients
Background and Aims: Among Human Immunodeficiency Virus (HIV)-infected individuals, Epstein-Barr virus (EBV) and Human Herpesvirus (HHV)-8 could cause significant illness as opportunistic infections. The purpose of the present study was to evaluate the prevalence of EBV and HHV-8 in saliva specimens obtained from HIV-1 infected Iranian individuals under the Highly Active Antiviral Therapy (HAAR...
متن کاملEpidemiology and pathogenesis of AIDS-related lymphomas.
Among patients with congenital and acquired immunodeficiencies, non-Hodgkin's lymphoma (NHLs ) are the most common tumors of the immune system. In the setting of human immunodeficiency virus (HIV) infection, as many as 10% to 20% of people ultimately developed NHLs. These tumors are clinically aggressive, frequently involve extranodal sites, and often exhibit unique features that distinguish th...
متن کاملTHE IN VITRO GROWTH PROPERTIES OF CELL LINES FROM EPSTEIN-BARR VIRUS-INDUCED TAMARIN TUMORS AND TAMARIN B CELLS TR ANSFORMED BY EPSTEIN BARR VIRUS
EBV-carrying human cell lines, depending on whether the cells are derived from Burkitt's lymphoma (BL) tumor biopsies or transformed by EBV in vitro, have different growth properties in vitro. In contrast, there are no clear differences between tamarin tumor lines and tamarin LCLs in vitro. Both types of tamarin cell lines could grow in agarose and formed colonies unlike human LCLs, althoug...
متن کاملHigh expression of latent membrane protein 1 of Epstein-Barr virus and BCL-2 oncoprotein in acquired immunodeficiency syndrome-related primary brain lymphomas.
Nearly all primary brain lymphomas in acquired immunodeficiency syndrome (AIDS) patients are associated withEpstein-Barr virus (EBV). The role of EBV in lymphomagenesis is not totally elucidated. One possible mechanism is the overexpression of the BCL-2 oncoprotein, because the latent membrane protein 1 (LMP1) has been reported to transactivate the bcl-2 gene in vitro. To study the interrelatio...
متن کامل