Ethanolic extract of Melia Azadirachta against Acetaminophen induced Nephrotoxicity

Aim of the study is to investigate the Nephroprotective activity of ethanolic extract taken from Melia azadirachta leaves, against APAP (Acetaminophen) induced nephrotoxicity. The phytochemical screening was carried out on the leaf extracts of Melia azadirachta, revealed the presence of active ingredients such as Phytol, Squalene, Oleic Acid, 2-Piperidinone, N-[4-bromo-n-butyl]. Leaves of Melia Azadirachta (MA) were successively extracted with ethanol and dried in powder form. The present study was conducted on group of male albino Wister rats. On the rats with APAP induced Nephrotoxicity, different concentration of MA powder extract such as, 250, 500, 750 mg/kg of body weight of rats administered orally. Significant changes were noticed in biochemical parameters (increases in serum urea, creatinine except uric acid) in APAP induced male albino Wister rats, which were restored towards normalization in Melia Azadirachta treated animals. Thus the present study ascertains that the leaf extract of Melia azadirachta possesses significant Nephroprotective activity.