Glucagon receptor recycling: role of carboxyl terminus, -arrestins, and cytoskeleton
نویسندگان
چکیده
Lada Krilov, Amy Nguyen, Teruo Miyazaki, Cecilia G. Unson, and Bernard Bouscarel Gastroenterology Research Laboratory, Digestive Diseases Center, Department of Biochemistry and Molecular Biology, The George Washington University, Washington, District of Columbia; Laboratory of Molecular Biology and Biochemistry, The Rockefeller University, New York, New York; and Department of Medicine, The George Washington University, Washington, District of Columbia
منابع مشابه
Glucagon receptor recycling: role of carboxyl terminus, beta-arrestins, and cytoskeleton.
Glucagon receptor (GR) activity and expression are altered in several diseases, including Type 2 diabetes. Previously, we investigated the mechanism of GR desensitization and internalization. The present study focused on the fate of internalized GR. Using both hamster hepatocytes and human embryonic kidney (HEK)-293 cells, we showed that internalized GR recycled to the plasma membrane within 30...
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