Abnormal brain connectivity in schizophrenia and bipolar disorder – a resting state functional MRI study
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Resting-state Functional Connectivity During Controlled Respiratory Cycles Using Functional Magnetic Resonance Imaging
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BACKGROUND Schizophrenia and bipolar disorder share overlapping symptoms and genetic etiology. Functional brain dysconnectivity is seen in both disorders. METHODS We compared 70 schizophrenia and 64 psychotic bipolar probands, their respective unaffected first-degree relatives (n = 70, and n = 52), and 118 healthy subjects, all group age-, gender-, and ethnicity-matched. We used functional ne...
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Bipolar disorder is characterized by a functional imbalance between hyperactive ventral/limbic areas and hypoactive dorsal/cognitive brain regions potentially contributing to affective and cognitive symptoms. Resting-state studies in bipolar disorder have identified abnormal functional connectivity between these brain regions. However, most of these studies used a seed-based approach, thus rest...
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BACKGROUND Schizophrenia and bipolar disorder share aspects of phenomenology and neurobiology and thus may represent a continuum of disease. Few studies have compared connectivity across the brain in these disorders or investigated their functional correlates. METHODS We used resting-state functional magnetic resonance imaging to evaluate global and regional connectivity in 32 healthy control...
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Functional connectivity of the resting-state (RS) brain is a vehicle to study brain dysconnectivity aspects of diseases such as schizophrenia and bipolar. Methods that are developed to measure functional connectivity are based on the underlying hypotheses regarding the actual nature of RS-connectivity including evidence of temporally dynamic versus static RS-connectivity and evidence of frequen...
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