Neurobiology of Disease Parkin Interacts with Ambra1 to Induce Mitophagy
نویسندگان
چکیده
Cindy Van Humbeeck,1* Tom Cornelissen,1* Hilde Hofkens,1 Wim Mandemakers,2,3 Kris Gevaert,4,5 Bart De Strooper,2,3 and Wim Vandenberghe1,6 1Department of Experimental Neurology and 2Center for Human Genetics, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium, 3Department of Molecular and Developmental Genetics, Flanders Institute for Biotechnology, B-3000 Leuven, Belgium, 4Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium, 5Department of Medical Protein Research, Flanders Institute for Biotechnology, B-9052 Ghent, Belgium, and 6Department of Neurology, University Hospitals Leuven, B-3000 Leuven, Belgium
منابع مشابه
Parkin interacts with Ambra1 to induce mitophagy.
Mutations in the gene encoding Parkin are a major cause of recessive Parkinson's disease. Recent work has shown that Parkin translocates from the cytosol to depolarized mitochondria and induces their autophagic removal (mitophagy). However, the molecular mechanisms underlying Parkin-mediated mitophagy are poorly understood. Here, we investigated whether Parkin interacts with autophagy-regulatin...
متن کاملAMBRA1-induced mitophagy: A new mechanism to cope with cancer?
Dysfunctions in mitophagy, the process by which mitochondria are eliminated, are associated with cancer. We found that the proautophagic protein AMBRA1 (activating molecule in beclin 1 regulated autophagy) binds the autophagosome adapter LC3, and that this interaction is crucial for mitochondrial clearance with or without involvement of the E3-ligase PARKIN. The discovery of a novel mitophagy p...
متن کاملThe effect of short endurance training on the expression level of PINK-1, Parkin and PGC-1α in the heart of nicotine-sensitized rats
Background: Nicotine alters the expression of various genes in the heart. PINK-1(PTEN-induced kinase1) is the major regulator of cellular mitophagy. Moreover, Parkin is a protein that plays a key role in the process of ubiquitination. Also, PGC-1ὰ (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is the main regulator of mitochondrial biogenesis. On the other hand, exercise...
متن کاملMolecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant
Mitochondrial dysfunction is characteristic of many neurodegenerative diseases. The Parkinson's disease-associated ubiquitin-protein ligase, Parkin, is important in the elimination of damaged mitochondria by autophagy (mitophagy) in a multistep process. Here, we show that a Parkin RING domain mutant (C289G) fails to redistribute to damaged mitochondria and cannot induce mitophagy after treatmen...
متن کاملNix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease
Therapeutic targets are needed to develop neuroprotective treatments for Parkinson's disease (PD). Mitophagy, the selective autophagic elimination of dysfunctional mitochondria, is essential for the maintenance of mitochondrial integrity and is predominantly regulated by the PINK1/Parkin-mediated pathway. Loss of function mutations in Parkin and PINK1 cause an accumulation of dysfunctional mito...
متن کامل